WordReference Random House Unabridged Dictionary of American English © 2025
designer drug′, 
  1. Drugsa drug produced by a minor modification in the chemical structure of an existing drug, resulting in a new substance with similar pharmacologic effects, esp. one created to achieve the same effect as a controlled or illegal drug.
  • 1980–85

Collins Concise English Dictionary © HarperCollins Publishers::
designer drug
  1. any of various narcotic or hallucinogenic substances manufactured illegally from a range of chemicals
  2. a drug designed to act on a specific molecular target

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